This article presents a comprehensive analysis of the circumstances surrounding the deaths of all deceased presidents of the United States of America. Based on historical documents, medical reports, and expert assessments, the chronology and causes of death of American heads of state are reconstructed. Particular attention is devoted to the eight presidents who died while in office, including four who fell at the hands of assassins and four who succumbed to natural causes. Statistical analysis covers natural mortality, assassinations, illnesses concealed from the public, as well as unique historical coincidences associated with the dates of presidential deaths.

This article examines the phenomenon of United States involvement in operations to eliminate foreign leaders, which has gained renewed attention in connection with the dramatic events of 2025–2026—the abduction of Venezuelan President Nicolás Maduro and the death of Iran's Supreme Leader Ali Khamenei in a joint US-Israeli strike. Based on analysis of historical documents, expert assessments, and international legal norms, the evolution of US approaches to using coercive methods for regime change is reconstructed. Particular attention is devoted to the contradiction between the official ban on political assassinations and the persistent practice of their application under new legal justifications.